I have been having trouble with my hands for a couple of years now, arthritis and carpel tunnel. I have tried braces for my wrists which helps intermittently. I started to use this and stopped after a few days. Then I decided to restart it. Now I have ordered 2 more bottles. It has helped slightly with my wrist pain, but, has helped more with my knees as I have a complex tears in my knee and don’t want to do a knee replacement. I have tried several other brands and tumeric but this does seem to be helping. I will continue to use as it takes time for healing.